描述

动态胃模型Dynamic Gastric Model（DGM）是一种基于人工智能的台式体外系统，可模拟人类胃部的消化过程，能够实时精准预测并解析食品或药物制剂的行为特性。该模型已应用于口服药物研发与食物消化研究超过20年，并通过与人体内研究的广泛对比验证。DGM通过模拟人胃的胃底/胃体与胃窦部位，精准复刻复杂的生化组成及胃部力学环境，这对预测活性药物成分（API）及口服剂型的生物行为至关重要。

DGM作为一种具备生理相关性的筛选工具，可为新型及现有食品、膳食方案和药物制剂的评估提供宝贵数据。该模型为预测化合物、营养素及配方在吸收前的转化路径提供了精准可靠的方法，因此将成为产品开发中机制研究、稳定性评估及生物利用度分析的重要工具。DGM可广泛应用于各类产品研发、药物发现与开发项目，涵盖新型功能性食品、药物递送系统以及活性成分与营养素的生物利用度研究。经改良的配方产品可与原研产品进行直接性能比对，仿制药与创新药之间亦可开展同等对比。

通过预测生物利用度或生物等效性，DGM能够加速药物与食品的研发进程，降低临床试验失败风险，并提供经全面验证的动物试验替代方案。

主要特征

• 精确复制胃混合液，剪切速率和蠕动。
• 为胃内容物提供准确的生化环境，允许进食和禁食比较不同食物类型的剂型行为。
• 与均质样品相反，具有研究多相餐食（即，真实食品和/或口服给药的药物制剂）消化能力的能力。
• 根据食物基质自动动态调整胃停留时间，酸和酶的添加量（数量和速率）以及生理过程。
• 可控制的胃排空和排泄。
• 在消化的所有阶段均可进行采样，从而可以进行实时收集和详细分析，以及针对特定隔室的建模。
• 全自动，易于使用和消毒。
• 提供有关消化过程的质量检查报告，包括停留时间，排空曲线，pH梯度，胃添加量/流速。

 

参考文献：

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